Cleveland Clinic researchers identify potential approach to treat heart disease through the gut.
Study identifies microbial inhibitor that prevents atherosclerosis; further confirms link between gut bacteria and cardiovascular disease.
Cleveland Clinic researchers have demonstrated – for the first time – that targeting microbes in the gut may prevent heart disease brought on by nutrients contained in a diet rich in red meat, eggs and high–fat dairy products. This novel approach centers around the research team’s previous discovery that TMAO, a byproduct formed in the gut during digestion of animal fats – is linked to atherosclerosis and heart disease.
Now, the team has identified a naturally occurring inhibitor called DMB ,that reduced levels of TMAO and reduced atherosclerosis in mice.
DMB is present in some balsamic vinegars, some red wines, and some cold-pressed extra virgin olive oils and grapeseed oils.
This discovery may represent a potential new therapeutic approach for the prevention of heart disease, the No. 1 killer in the United States, as well as other metabolic diseases linked to gut microbes, such as diabetes. The current research was published both online and in the Dec. 17 print edition of Cell.